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MCj03645040000[1]Product Spotlight:  Phosphodiesterases

 

 

 

Background: Cyclic nucleotide phosphodiesterases (PDEs) degrade the phosphodiester bond in cAMP and cGMP.  PDEs are important regulators of signal transduction mediated by these second messenger molecules. PDE enzymes are important targets for pharmacological inhibition due to their unique tissue distribution, structural properties, and functional properties.

 

The most well-known PDE inhibitor, Viagra (sildenafil), inhibits PDE5A to treat erectile dysfunction.  However, many other PDEs are potential drug targets for pulmonary arterial hypertension, coronary heart disease, dementia, depression, and schizophrenia. For example, PDE3 is located primarily in myocardium, so PDE3 inhibitors are being investigated in cardiology studies, while PDE4 is involved in inflammation and immunity, and PDE4 inhibitors are potential treatments for asthma.

 

Product Line: BPS provides one of the most extensive offerings of PDE isozymes available (24 enzymes), as well as 6 different assay kits for screening inhibitors of PDE isozyme activity.  Additionally, we offer two PDE-expressing cell lines (PDE1b and PDE10A), which will be of interest to drug discovery researchers performing whole cell assays.  Finally, BPS also offers PDE selectivity profiling services using customer-assembled PDE panels.

 

60010

PDE PDE1A

10 µg

362 €

60011

PDE PDE1B

10 µg

362 €

60012

PDE PDE1C

10 µg

362 €

60020

PDE PDE2A

5 µg

362 €

60030

PDE PDE3A

10 µg

362 €

60031

PDE PDE3B

10 µg

362 €

60040

PDE PDE4A1A

10 µg

362 €

60041

PDE PDE4B1

10 µg

362 €

60042

PDE PDE4B2

5 µg

362 €

60044

PDE PDE4C1

5 µg

362 €

60043

PDE PDE4D2

5 µg

362 €

60046

PDE PDE4D3

5 µg

362 €

60051

PDE PDE5A (mouse)

5 µg

362 €

60050

PDE PDE5A1

10 µg

362 €

60060

PDE PDE6C

10 µg

362 €

60070

PDE PDE7A

10 µg

362 €

60071

PDE PDE7B

10 µg

362 €

60080

PDE PDE8A1

10 µg

362 €

60090

PDE PDE9A2

10 µg

362 €

60101

PDE PDE10A (mouse)

10 µg

362 €

60102

PDE PDE10A (rat)

5 µg

362 €

60100

PDE PDE10A1

10 µg

362 €

60110

PDE PDE11A4

10 µg

362 €

60300

PDE PDE Assay Kit 

 100 reactions 

440 €

60311

PDE PDE1B Assay Kit

 100 reactions 

440 €

60320

PDE PDE2A Assay Kit

 100 reactions 

440 €

60340

PDE PDE4A Assay Kit

 100 reactions 

440 €

60345

PDE PDE4D Assay Kit

 100 reactions 

440 €

60400

PDE PDE10A Assay Kit

 100 reactions 

440 €

 

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