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TRANSIL® Brain Absorption Kit

A ready-to-use kit for rapid assessment of drugs' ability to cross the blood brain barrier

A novel ready-to-use kit designed for rapid assessment of drug candidates' ability to cross the blood brain barrier. The kit only requires the addition of drug candidates to the microtiter wells followed by a 2-minute incubation. The kit assesses the affinity of the drug candidates to brain membrane. Membrane affinity is directly related to permeation and blood-to-brain absorption of a drug.

Benefits

  • Fast, requiring only 2 minutes for incubation.
  • Accurate. Measures the affinity of the drug candidate to the brain membrane.  More accurate classification of CNS compounds measured by brain availability and brain membrane affinity, compared to PAMPA BBB (Parallel Artificial Membrane Permeability Assay Blood Brain Barrier) (86% vs. 62%, respectively).
  • Reliable with highly reproducible results, and robust correlation to dialysis.
  • Relevant. Used in combination with plasma binding protein data, determine the free fraction in brain and the equilibrium distribution of drug compounds between blood and brain tissue.
  • Ready-to-use format plated in 96-well or ready-to-use tubes in strips of 8. Kit requires only addition of test material, 2-minute incubation, and quantification.
  • Flexible. Adaptable to automation.

Product Information

 

Product Number Product Name Format
TMP-0110-0096 Transil® Brain Absorption Kit 96-well plate
TMP-0110-1196 Transil® Brain Absorption Kit 96-well (strips)

 

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