The Acidities of Nucleophilic Monofluoromethylation Reagents: An Anomalous α-Fluorine Effect

Fluorine is essentially the most electronegative ingredient within the Periodic Table. Fluorine incorporation into natural molecules is predicted to decrease the p Okay a of neighboring performance by way of its sturdy electron-withdrawing impact, and this technique has been broadly exploited in various disciplines. Herein, we report a hanging anomalous a -fluorine substitution impact on

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